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| April 2001 | Record: 16-9 | |||||
| Home: 11-5, Avg Att: 31,730 - Road: 5-4, Avg Att: 37,647 | ||||||
| Date | Day | Time | Opponent/Result | Record | Location | Attendance |
| 2 | Monday | 3:05 | Orioles 2, Red Sox 1 | 0-1 | Baltimore | 46,547 |
| 4 | Wednesday | 7:05 | Red Sox 3, Orioles 0 | 1-1 | Baltimore | 35,602 |
| 5 | Thursday | 7:05 | Orioles 2, Red Sox 1 | 1-2 | Baltimore | 33,469 |
| 6 | Friday | 1:05 | Red Sox 11, Devil Rays 4 | 2-2 | Boston | 33,525 |
| 7 | Saturday | 6:05 | Red Sox 6, Devil Rays 2 | 3-2 | Boston | 31,660 |
| 8 | Sunday | 1:05 | Red Sox 3, Devil Rays 0 | 4-2 | Boston | 31,383 |
| 10 | Tuesday | 6:05 | Red Sox 10, Orioles 1 | 5-2 | Boston | 27,664 |
| 11 | Wednesday | 6:05 | Orioles 5, Red Sox 4 | 5-3 | Boston | 26,302 |
| 12 | Thursday | 6:05 | Red Sox 8, Orioles 2 | 6-3 | Boston | 30,083 |
| 13 | Friday | 6:05 | Red Sox 3, Yankees 2 | 7-3 | Boston | 33,124 |
| 14 | Saturday | 1:05 | Yankees 3, Red Sox 2 | 7-4 | Boston | 33,396 |
| 15 | Sunday | 1:05 | Red Sox 5, Yankees 4 | 8-4 | Boston | 32,127 |
| 16 | Monday | 11:05 | Red Sox 8, Yankees 1 | 9-4 | Boston | 33,373 |
| 17 | Tuesday | 7:15 | Red Sox 10, Devil Rays 0 | 10-4 | Tampa Bay | 19,433 |
| 18 | Wednesday | 7:15 | Red Sox 9, Devil Rays 1 | 11-4 | Tampa Bay | 16,622 |
| 19 | Thursday | 7:15 | Red Sox 8, Devil Rays 3 | 12-4 | Tampa Bay | 22,026 |
| 20 | Friday | 7:05 | Yankees 6, Red Sox 1 | 12-5 | New York | 54,366 |
| 21 | Saturday | 1:05 | Red Sox 8, Yankees 3 | 13-5 | New York | 55,483 |
| 22 | Sunday | 1:05 | Yankees 4, Red Sox 3 | 13-6 | New York | 55,278 |
| 24 | Tuesday | 7:05 | Red Sox 9, Twins 4 | 14-6 | Boston | 32,557 |
| 25 | Wednesday | 7:05 | Twins 6, Red Sox 4 | 14-7 | Boston | 33,177 |
| 26 | Thursday | 7:05 | Red Sox 2, Twins 0 | 15-7 | Boston | 32,222 |
| 27 | Friday | 7:05 | Red Sox 9, Royals 2 | 16-7 | Boston | 31,850 |
| 28 | Saturday | 1:05 | Royals 8, Red Sox 2 | 16-8 | Boston | 32,442 |
| 29 | Sunday | 1:05 | Royals 11, Red Sox 8 | 16-9 | Boston | 32,791 |
| May 2001 | Record: 13-13 | |||||
| Home: 6-5, Avg Att: 32,320 - Road: 7-8, Avg Att: 30,398 | ||||||
| Date | Day | Time | Opponent/Result | Record | Location | Attendance |
| 1 | Tuesday | 10:05 | Red Sox 2, Mariners 0 | 17-9 | Seattle | 36,642 |
| 2 | Wednesday | 10:05 | Mariners 5, Red Sox 1 | 17-10 | Seattle | 40,170 |
| 3 | Thursday | 10:05 | Mariners 10, Red Sox 3 | 17-11 | Seattle | 32,513 |
| 4 | Friday | 10:05 | A's 7, Red Sox 3 | 17-12 | Oakland | 20,631 |
| 5 | Saturday | 4:05 | Red Sox 7, A's 1 | 18-12 | Oakland | 29,248 |
| 6 | Sunday | 8:05 | Red Sox 5, A's 4 | 19-12 | Oakland | 40,186 |
| 8 | Tuesday | 7:05 | Red Sox 12, Mariners 4 | 20-12 | Boston | 32,941 |
| 9 | Wednesday | 7:05 | Mariners 10, Red Sox 5 | 20-13 | Boston | 31,616 |
| 10 | Thursday | 7:05 | Mariners 5, Red Sox 2 | 20-14 | Boston | 31,428 |
| 11 | Friday | 7:05 | A's 7, Red Sox 6 | 20-15 | Boston | 32,718 |
| 12 | Saturday | 1:05 | Red Sox 9, A's 3 | 21-15 | Boston | 32,686 |
| 13 | Sunday | 1:05 | Red Sox 5, A's 4 | 22-15 | Boston | 31,926 |
| 15 | Tuesday | 8:05 | Red Sox 5, Twins 2 | 23-15 | Minnesota | 15,332 |
| 16 | Wednesday | 8:05 | Twins 4, Red Sox 3 | 23-16 | Minnesota | 22,006 |
| 17 | Thursday | 1:05 | Twins 5, Red Sox 3 | 23-17 | Minnesota | 18,466 |
| 18 | Friday | 8:05 | Red Sox 6, Royals 3 | 24-17 | Kansas City | 34,154 |
| 19 | Saturday | 8:05 | Royals 5, Red Sox 2 | 24-18 | Kansas City | 26,583 |
| 20 | Sunday | 2:05 | Red Sox 10, Royals 3 | 25-18 | Kansas City | 18,596 |
| 23 | Wednesday | 7:05 | Yankees 7, Red Sox 3 | 25-19 | New York | 44,108 |
| 24 | Thursday | 1:05 | Yankees 2, Red Sox 1 | 25-20 | New York | 55,592 |
| 25 | Friday | 7:05 | Red Sox 4, Blue Jays 0 | 26-20 | Boston | 32,912 |
| 26 | Saturday | 5:05 | Blue Jays 5, Red Sox 0 | 26-21 | Boston | 31,035 |
| 27 | Sunday | 1:05 | Red Sox 4, Blue Jays 2 | 27-21 | Boston | 31,420 |
| 28 | Monday | 7:05 | Yankees 4, Red Sox 3 | 27-22 | Boston | 33,125 |
| 30 | Wednesday | 7:05 | Red Sox 3, Yankees 0 | 28-22 | Boston | 33,711 |
| 31 | Thursday | 7:05 | Red Sox 11, Blue Jays 5 | 29-22 | Toronto | 21,747 |
| June 2001 | Record: 17-11 | |||||
| Home: 8-8, Avg Att: 32,948 - Road: 9-3, Avg Att: 29,135 | ||||||
| Date | Day | Time | Opponent/Result | Record | Location | Attendance |
| 1 | Friday | 7:05 | Red Sox 6, Blue Jays 4 | 30-22 | Toronto | 21,564 |
| 2 | Saturday | 4:05 | Red Sox 2, Blue Jays 1 | 31-22 | Toronto | 24,603 |
| 3 | Sunday | 1:05 | Red Sox 5, Blue Jays 4 | 32-22 | Toronto | 24,653 |
| 4 | Monday | 1:05 | Yankees 7, Red Sox 6 | 32-23 | New York | 41,771 |
| 5 | Tuesday | 7:05 | Red Sox 4, Tigers 3 | 33-23 | Boston | 32,814 |
| 6 | Wednesday | 7:05 | Tigers 7, Red Sox 3 | 33-24 | Boston | 32,794 |
| 7 | Thursday | 7:05 | Red Sox 8, Tigers 1 | 34-24 | Boston | 32,132 |
| 8 | Friday | 7:05 | Red Sox 3, Phillies 2 | 35-24 | Boston | 33,435 |
| 9 | Saturday | 1:15 | Phillies 5, Red Sox 2 | 35-25 | Boston | 32,944 |
| 10 | Sunday | 1:05 | Red Sox 5, Phillies 4 | 36-25 | Boston | 32,767 |
| 12 | Tuesday | 7:05 | Red Sox 4, Marlins 2 | 37-25 | Boston | 32,816 |
| 13 | Wednesday | 7:05 | Marlins 4, Red Sox 2 | 37-26 | Boston | 32,637 |
| 14 | Thursday | 6:05 | Red Sox 6, Marlins 4 | 38-26 | Boston | 33,225 |
| 15 | Friday | 7:40 | Red Sox 9, Braves 5 | 39-26 | Atlanta | 48,469 |
| 16 | Saturday | 7:10 | Braves 8, Red Sox 0 | 39-27 | Atlanta | 50,524 |
| 17 | Sunday | 1:10 | Red Sox 4, Braves 3 | 40-27 | Atlanta | 45,362 |
| 19 | Tuesday | 7:15 | Red Sox 5, Devil Rays 4 | 41-27 | Tampa Bay | 12,950 |
| 20 | Wednesday | 7:15 | Red Sox 8, Devil Rays 2 | 42-27 | Tampa Bay | 12,520 |
| 21 | Thursday | 7:15 | Red Sox 7, Devil Rays 4 | 43-27 | Tampa Bay | 15,603 |
| 22 | Friday | 7:05 | Blue Jays 4, Red Sox 3 | 43-28 | Boston | 33,844 |
| 23 | Saturday | 5:05 | Blue Jays 9, Red Sox 6 | 43-29 | Boston | 33,266 |
| 24 | Sunday | 1:05 | Blue Jays 5, Red Sox 2 | 43-30 | Boston | 32,804 |
| 25 | Monday | 7:05 | Red Sox 12, Devil Rays 8 | 44-30 | Boston | 32,854 |
| 26 | Tuesday | 7:05 | Red Sox 7, Devil Rays 6 | 45-30 | Boston | 32,185 |
| 27 | Wednesday | 7:05 | Devil Rays 9, Red Sox 7 | 45-31 | Boston | 33,216 |
| 28 | Thursday | 7:05 | Devil Rays 4, Red Sox 3 | 45-32 | Boston | 33,433 |
| 29 | Friday | 7:05 | Blue Jays 8, Red Sox 4 | 45-33 | Toronto | 23,055 |
| 30 | Saturday | 6:05 | Red Sox 7, Blue Jays 5 | 46-33 | Toronto | 28,543 |